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GH receptor signaling in skeletal muscle and adipose tissue in human subjects following exposure to an intravenous GH bolus

For practical comparison: | Property | Native IGF-1 | IGF-1 DES | IGF-1 LR3 | |---|---|---|---| | Amino acids | 70 | 67 | 83 | | Half-life | ~10 min | ~20-30 min | ~20-30 h | | IGFBP-3 affinity | High | Low | Very low (~1,000x reduced) | | Relative IGF-1R potency | 1x | ~10x | ~2-3x | | Systemic vs

And like other unapproved drugs, peptides like Epitalon that are bought from an unregulated gray-market source have the risk of toxicity, contamination, and unknown dosing and potency

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Typical daily range: 2.55 mg once or twice daily (subcutaneous)