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The major drawback to using VLP as a drug delivery strategy is that, because of its viral proteinaceous particle and easy uptake by dendritic cells, it triggers an innate immune response (145)

Agius R, Pace NP, Fava S

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ABSTRACT Potentially deadly drug rashes include Stevens-Johnson syndrome/toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, acute generalized exanthematous pustulosis, and drug-induced vasculitis