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Vitamin C, for instance, neutralizes free radicals by donating electrons (Na et al., 2006

Therefore, mitochondrial dysfunction prevents cells from meeting their energy requirements and involves impairment of neuronal communication, cellular resilience, and hippocampal neurogenesis, which leads to mood and psychiatric disorders (Perkins et al., 1997

Moreover, after caloric restriction, obese subjects showed weight loss together with ameliorated IR, reduced ER stress markers and improved mitochondrial function [53], suggesting the link between ER stress and abnormal lipid metabolism/IR

On the antioxidant hypothesis with regard to arteriosclerosis

J Natl Cancer Inst 98 : 139143 Moon JW et al