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7 This predictive system is driven by a circadian oscillator in the suprachiasmatic nucleus of the brain and is entrained to the ambient lightdark cycle

Approximately 50%60% of diabetic ulcer patients develop infections, and about 20% of these cases, involving moderate to severe infections, require lower extremity amputation (Matoori et al., 2021)

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Its main pathological features involve pathological retinal neovascularization, bloodretinal barrier (BRB) and retinal thinning, and the degeneration of neurons, driven by multiple interrelated factors, including glucotoxicity, OS, inflammation, and hypoxia-driven growth factor secretion (87)

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