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As cysteine and glutathione are scavengers of free radicals (mainly reactive oxygen species (ROS)), they can abrogate the effects of the majority of oxidative or alkylating drugs used in cancer therapy, affording an important resistance mechanism

We showed that the GCLC mRNA expression level was downregulated by ACTL6A KD and was upregulated when ACTL6A was overexpressed, but the GCLM expression was not changed (Supplementary Fig 5a, b)

Mar 30 2021 Holt et al., Thorax, doi:10.1136/thoraxjnl-2021-217487 Risk factors for developing COVID-19: a population-based longitudinal study (COVIDENCE UK) 56% fewer cases (p=0.41)

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