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G., & Constantinou-Kokotou, V

& Tang, S

Sirtuin 5 alleviates liver ischemia/reperfusion injury by regulating mitochondrial succinylation and oxidative stress

However, there are many medical conditions that affect the disposition of low Vd drugs in a patient (e.g., nonsteroidal anti-inflammatory drugs and aminoglycosides), and these drugs do require dosage adjustment because of their narrow therapeutic index