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Addition of hydrophobic methyl group substitutions around the quinolinium scaffold (previously shown to negatively impact NNMT inhibitory activity) only slightly improved membrane permeability via passive transport as indicated by the low, but non-zero, permeability values for 1,8-diMQ and 1,2,4,8-tetraMQ (Table 4)

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A study from Archive Pharmacal Research has suggested it may have a stimulating effect on hair follicles, and while the overall volume of copper peptide hair research still leans toward GHK-Cu, AHK-Cu continues to be studied for its hair-specific potential

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