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10.1016/j.cell.2009.03.045 64 KreJ

Lorsque le glutathion rduit neutralise un radical libre, il soxyde et se transforme en GSSG

Bioinform 26 (2), bbaf109

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Mechanistically, this combination is also expected to reduce intracellular methionine availability by increasing anabolic demand (via GCN2 inhibition) while imposing oxidative and metabolic stress (via GCLC inhibition), creating a state of methionine limitation without the normal GCN2-mediated adaptive response