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Declining estrogen and progesterone, combined with relative androgen dominance, can trigger diffuse thinning across the scalp

Altogether, these findings show that the expression of Esm1 in the intestinal vascular network commences during embryogenesis and persists into postnatal and adult stages

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Although there are still challenges to overcome, patient-derived organoids represent a potential preclinical model (Zainal Abidin et al., 2017)

PMID: 20386931