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Importantly, expression levels of these genes have been used in numerous studies as sensitive indices for oxidative stress 8,19,20

Cell Mol Gastroenterol Hepatol (2021) 11:55171

Metabolic substrate processing involves precise enzymatic degradation of toxic substances, including lipofuscin and advanced glycation end products (AGEs) [40]

In vitro and preclinical studies demonstrate that inhibiting key regulators (e.g., GPX4) effectively induces ferroptosis, reducing GBM cell viability and tumor growth [11]