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Incretin-based therapy for diabetes prevention in patients with obesity In agreement with what has been previously shown for any weight-lowering lifestyle intervention and medication, regardless of their mechanism of action 18 , incretin-based AOM have been associated with amelioration of glucose metabolism and T2D prevention (Fig

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However, as with any biological therapy, the theoretical possibility of individual hypersensitivity cannot be entirely eliminated, and appropriate monitoring remains prudent

Several ATP-competitive CDK6 inhibitors (e.g., palbociclib, ribociclib) have been reported, but these are not very selective and are associated with serious side effects, such as neutropenia

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