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In contrast to normal EGFR internalization, the Cisplatin-dependent EGFR endocytosis does not require ubiquitination, but is Dynamin- and AP-2 dependent

& Katz, J

Safety profile and dosing in research Across preclinical studies, no toxic or lethal dose of BPC-157 has been identified across a remarkably wide dosing range, from 6 micrograms per kilogram to 20 milligrams per kilogram