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In vivo and in vitro models, the modulation of xCT and EAAC1 expression by oxidative stress stimuli has been widely reported (Muguruma et al., 2007

Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis

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Gene expression profiling of long-lived dwarf mice: longevity-associated genes and relationships with diet, gender and aging

The different nature of these residues is suggested to be responsible for the differences in catalytic properties of mesophilic and extremophilic GGTs ( FIGURE 5 Recent crystallographic studies on L-Glu-bound BlGGT demonstrated that its active site channel constitutes two extensive pockets at the intersubunit interface lined mainly by hydrophobic residues