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How Glutathione Works Glutathione competitively inhibits melanin synthesis in the reaction of tyrosinase and L-DOPA by interrupting L-DOPAs ability to bind to tyrosinase during melanin synthesis

Int J Toxicol 30(Suppl 3):149S-227S Jovanovic ML, McMahon JM, McNett DA, Tobin JM, Plotzke KP (2008) In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14CD4) and 14C-decamethylcyclopentasiloxane (14CD5)

The reaction mechanism for roGFP2(S 2 ) as a model non-glutathione disulfide substrate resembles the first part of the GSH-dependent reduction of the sulfenic acid of human peroxiredoxin 6 that is catalyzed by glutathione transferase P1-1 (which shares several structural features with glutaredoxins) 7,80,81,82

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doi: 10.3389/fimmu.2019.02349 131 WangXLiuHChenJHuangYLiLRampersadSet al