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One of the key mechanisms through which nicotinamide may exert these protective effects is by restoring the levels of nicotinamide adenine dinucleotide (NAD+), which is critical for mitochondrial metabolism and energy production

Mande SS, Sarfaty S, Allen MD, Perham RN, Hol WG (1996) Proteinprotein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase

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GPX3 complementary DNA (cDNA) were PCR amplified from a cDNA library of human cell line and then a homologous recombination vector was constructed by cloning it into an empty FlagpcDNA3 vector

[PubMed] Guoyao Wu