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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations GSH: reduced glutathione GSSG: glutathione disulfide GS: thyil radical ROS: reactive oxygen species RNS: reactive nitrogen species RS: reactive species -GCS: -glutamylcysteine synthetase GPX: glutathione peroxidase GR: glutathione reductase GST: glutathione S -transferase GSNO: nitrosoglutathione G6PD: glucose-6-phosphate dehydrogenase NAC: N -acetyl-L-cysteine NO: nitric oxide protein-SSG: protein glutathionylation protein-SNO: protein nitrosylation References Galluzzi L, Maiuri MC, Vitale I, Zischka H, Castedo M, Zitvogel L et al

Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD

Peppa M, Stavroulakis P, Raptis SA

Damian Holsinger, The University of Sydney, Australia Reviewed by Muhammad Usman Munir, Jouf University, Saudi Arabia Omamuyovwi Meashack Ijomone, University of Medical Sciences, Ondo, Nigeria Updates Copyright 2025 Yassin, Skrabulyte-Barbulescu, Alshamsi, Saeed, Alkuwaiti, Almazrouei, Alnuaimi, BaniYas, Aldhaheri, Alderei, Shehab and Hamad