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Whereas most of these reversible modifications lead to protein inactivation, S-sulfhydration can be distinct since it usually activates the targeted proteins as shown for GAPDH and p65 ( All these observations suggest that there may be biological differences for each of these different PTMs and possibly hierarchies

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While there was no control group included, the placebo response in such refractory patients is notoriously low, and this response rate therefore is quite encouraging

S., Balducci, A

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses