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In laboratory investigations, researchers found that NNMT overexpression correlates with obesity and metabolic dysfunction, while its inhibition produces remarkable metabolic benefits

Furthermore, we comprehensively analyzed the metabolites that have been associated with DED

These mutations can result in various diseases, given the critical role of mitochondria in nucleated cells

However, to our knowledge, this is the first systematic review to evaluate such a large number of indices of oxidative stress and it highlights the role that this complex phenomenon can play in the pathophysiology of this disease

Nady Braidy is the recipient of an Alzheimers Australia Viertel Foundation Postdoctoral Research Fellowship at the University of New South Wales