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Pyroptosis may affect specific brain regions or cell types in different ways, thereby contributing to disease progression in neurodegenerative disease (Xu et al., 2024)

Abbreviations Ala: Alanine ALDH18A1: Aldehyde dehydrogenase 18 family member A1 AMPK: Adenosine 5-monophosphate (AMP)-activated protein kinase ANXA2: Annexin A2 aPDL1: Anti-PDL1 antibody AREG: Amphiregulin ARPC1A: Actin-related protein 2/3 complex subunit 1 A ASCT2: Alanine-serine-cysteine transporter 2 ASNS: Asparagine synthetase Asp: Aspartic acid ATF4: Activating transcription factor 4 AZA: Azacytidine BBR: Berberine BC: Breast cancer BCa: Bladder cancer cAMP: Cyclic adenosine monophosphate CAR-T: Chimeric antigen receptor-T CD69: Cell adhesion molecule 69 CD8: Cytotoxic T Lymphocyte Antigen 8 cDC1: Type 1 conventional dendritic cells CEMIP: Cell migration-induced hyaluronan-binding protein circRNAs: Circular RNAs c-MYC: Myelocytomatosis viral oncogene homolog CQ: Chloroquine CRC: Colorectal cancer CSC: Cancer stem cells CTGF: Connective tissue growth factor CTL: Cytotoxic T lymphocyte DON: 6-diazo-5-oxo-l-norleucine ECM: Extracellular matrix EGFR: Epidermal growth factor receptor EMT: Epithelial-mesenchymal transition EphA2: Erythropoietin-producing hepatocellular A2 ERK: Extracellular regulated protein kinases ESCC: Esophageal squamous cell carcinoma FA-DCNP: Folic acid-targeted nanoparticles FAO: Fatty acid -oxidation FAs: Fatty acids FLIP: FLICE-inhibitory protein GABA: -aminobutyric acid GAD: Glutamic acid decarboxylase GBM: Glioblastoma GC: Gastric carcinoma GCN5: General control non-derepressible 5 GDH: Glutamine dehydrogenase Gln: Glutamine GLS: Glutaminase Glu: Glutamic acid GLUD: Glutamate dehydrogenase GLUL: Glutamate-ammonia ligase GLULH: Glutathione GLUT1: Glucose transporter 1 GMII: Glutamine metabolism immunity index GOT1: Glutamate-oxaloacetate transaminase 1 GPCRs: G protein-coupled receptors GS: Glutamine synthetase Gsk3: Glycogen synthase kinase 3 GZMB: Granzyme B HCC: Hepatocellular carcinoma HDAC: Histone deacetylase HEPG: Hepatocellular carcinoma HNSCC: Head and neck squamous cell carcinoma hSPAR: Human SPAR ICB: Immune checkpoint blockade IFN-: Interferon- IL-1: Interleukin-1 IL-6: Interleukin-6 JAK: Janus kinase Keap1: Kelch-like ECH-associated protein 1 LAT2: L-amino acid transporter protein 2 LATS: Large tumor suppressor kinase LDHA: Lactate dehydrogenase LNCaP: Human prostate cancer cells lncRNAs: Long-stranded non-coding RNAs LND: Lonidamine LPO: Lipid peroxidation LUAD: Lung adenocarcinoma M1-TAMs: M1-type macrophages M2-TAMs: M2-type macrophages MDS: Myelodysplastic syndromes MM: Multiple myeloma MoS2: Molybdenum disulfide MRPL35: Mitochondrial ribosomal protein L35 MSO: l-methionine sulfoximine mTORC1: Mechanistic target of rapamycin complex 1 MZF1: Myeloid zinc finger 1 NADH: Nicotinamide adenine dinucleotide NADPH: Nicotinamide adenine dinucleotide phosphate hydrogen ncRNAs: Non-coding RNAs NetG1: Netrin G1 NF-B: Nuclear factor kappa-B NKT: Natural killer T NSCLC: Non-small cell lung cancer NSUN2: NOP2/Sun RNA methyltransferase 2 OA: Oleic acid OAA: Oxaloacetic acid OC: Ovarian cancer OSCC: Oral squamous cell carcinoma OTUD4: OTU deubiquitinase 4 OXPHOS: Oxidative phosphorylation PC: Pancreatic cancer PCa: Prostate cancer PDAC: Pancreatic ductal adenocarcinoma PHGDH: Phosphoglycerate dehydrogenase PKA: Protein kinase A PM: Particulate matter PRF1: Perforin 1 PSAT1: Phosphatidylserine aminotransferase 1 PTC: Papillary thyroid carcinoma PYCR1: Pyrroline-5-carboxylic acid reductase 1 RA: Retinoic acid ROS: Reactive oxygen species rRNA: ribosomal RNA S100A2: S100calcium-binding protein A2 SCLC: Small cell lung cancer SIRT4: Sirtuin 4 SLC1A5-AS: SLC1A5 antisense long non-coding RNA SLC38A2: Solute carrier family 38 member 2 SREBP-1: Sterol regulatory element binding transcription factor 1 SSP: Synthesis pathway STAB1: SATB homeobox 1 STAT3: Signal transducer and activator of transcription TARBP1: TAR (HIV-1) RNA-binding protein 1 TAZ: Transcriptional coactivator with PDZ-binding motif TC2N: Tandem C2 structural domain nuclear protein TCA: Tricarboxylic acid cycle TEAD: TEA domain transcription factor TGM2: Glutamine transaminase 2 TME: Tumour microenvironment TNBC: Triple-negative breast cancer TRAIL-R2: TNF-related apoptosis-inducing ligand receptor 2 tRNA: Transfer RNA TrxR: Thioredoxin reductase UPS: Ubiquitin-proteasome system YAP: Yes-associated protein -KG: -Ketoglutarate References Vander Heiden MG, DeBerardinis RJ

Serving as the first barrier for circulating molecules and cells, ECs represent the main regulators of vascular homeostasis being able to respond to environmental changes, either physical or chemical signals, by producing several factors that regulate vascular tone and cellular adhesion

The quantitative results were presented in LAU/mm 2 , which means relative count intensity in specific area

pylori does appear to inflame neurons (Shen X