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The first patient was dosed in July 2012

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GPX specifically catalyses the reduction of lipid hydroperoxides (LOOHs) and organic hydroperoxides (ROOHs) through glutathione (GSH)-dependent reactions, thereby minimising oxidative damage and regulating prostaglandin biosynthesis [28]

Vercammen D, Beyaert R, Denecker G et al (1998) Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor