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It usually occurs due to decreased dopamine production due to dopaminergic neuronal death in the midbrain's substantia nigra, leading to striatal dopamine deficiency, which is responsible for the motor symptoms of PD [2]

doi: 10.1097/jnr.0000000000000469 27 ChangK.-T.AnishkinA.PatwardhanG

TFEB, a member of the MiT/TFE family, has been found to directly bind with the CLEAR element and further promote lysosomal renewal 92

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We look forward to continuing our wellness journey with them