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First, it maps nano-design variables to measurable BBB outcomes, identifying which features consistently track with improved brain exposure across studies

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Peptides have short half-life, and metabolize quickly, leaving short detection windows in urine

There are also findings that suggest an increase in mitophagy in some animal models of ocular neurodegeneration

In another study, -Gal A-deficient endothelial cells showed the degradation of the glycocalyx by heparinases because of an inflammatory response and the authors suggested that this might explain the endothelial dysfunction observed in Fabry patients [61]