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Furthermore, TGP activates the PI3K/Akt signaling pathway to enhance melanocyte survival, while also inhibiting the NF-B pathway to reduce pro-inflammatory cytokine release and inflammation-induced melanocyte damage ( 10 Problems with current research and directions for future research 10.1 Problems with current research Research on TGP in the treatment of dermatologic diseases has demonstrated significant anti-inflammatory, immunomodulatory, and antioxidant effects, but there are several limitations

Thus, we concluded that GD-mediated sequential phosphorylation of SIRT7 by AMPK and GSK3 facilitates its binding to SKP2, which prevents SKP2 S256 phosphorylation by AMPK

2024b).While increased glycolytic flux ensures adequate ATP production, we propose that its overactivation might negatively impact the functionality of the pentose phosphate pathway

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