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Combination therapy with melphalan is under clinical trials to determine whether BSO can help sensitize resistant neuroblastoma [70]

But with any hormone-based therapy, its important to ask the right questionsespecially when it comes to

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doi: 10.1016/j.gene.2017.11.049 122 ZhaoHZhaoYLiTLiMLiJLiRet al

Therapeutic strategies against antithyroid drugs-induced hepatotoxicity In many cases of antithyroid drugs-induced hepatic injury, no standard and specific treatment is available, except of drug discontinuation and monitoring patients' liver function during hospitalization.27,98 The most performed laboratory tests in antithyroid drugs-induced hepatotoxicity cases, are liver function tests as evaluated by serum aminotransferase levels (AST & ALT) and alkaline phosphatase (ALP) activity.8,99 Other assessments involve serum bilirubin, white blood cells count, prothrombin time (PT), and serum thyroid hormones and TSH levels.99,100 Moreover, abdominal ultrasonography is done to detect any cholestatic changes of patients' liver.6 Drug-induced hepatic injury could be certainly proven when other interacting factors such as viral hepatitis are ruled out