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Moreover, microbial transplantation studies in germ-free mice with human commensals containing a functional (but not a deletion mutant) microbial cutC gene (responsible for cholineTMA transformation) (23) and genetic manipulation (both gain of function and loss of function) of host hepatic flavin monooxygenase 3 have been shown to modulate host TMAO levels, platelet responsiveness, and thrombosis potential in vivo (24)

Housing, handling, and experimental procedures were approved by the University of Haifa Institutional Committee for animal experiments in accordance with National Institutes of Health guidelines

Besides SOD and APX that directly scavenge ROS, this cycle also involves other enzymes such as MDHAR, DHAR, and GR, which act as antioxidant-regenerating enzymes that regenerate GSH and ASA from their oxidized forms (Mittler, 2002

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

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