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Originating from harmful and excessive free radicals, a shortage of NRF2 leads to the dysregulation of skin fibroblasts, resulting in reduced collagen I biosynthesis, and diminished collagen fibril deposition 11

G.et al (2018)

In the pathogen defense-related ROS regulation pathway, most genes were upregulated in Xcc -infected samples of the R line compared with the Xcc -infected samples of the S line, including PRX34 , GLP1 , HUP39 , CAT2 , CAT3 , APX2 , and APX5 genes

Rescue experiments reveal that vitamin E is essential for preventing necroptotic cell death and suppressing anemia caused by GPX4 deletion [10]

Aging and Free Radicals With age, the bodys natural glutathione production declines, leading to dull skin and tired appearance