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GO analysis delivered an enrichment of hypermethylated DMPs/genes, in biological processes involved in the regulation of cellular adhesion and signaling, including regulation of wound healing, spreading of epidermal cells (p=0.01), negative regulation of cell-substrate junction organization (p=0.03) and negative regulation of focal adhesion assembly (p=0.03) ( Figure 1E

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This study demonstrated that MgIG significantly inhibited the protein expression of COX-2 and 5-LOX, key enzymes in both metabolic pathways of arachidonic acid induced by LPS (Xie et al., 2015) (Figure 4)

Osteoblasts and osteoclasts functions are regulated by a system of neuropeptides from the central nervous system, which helps maintain the balance between bone formation and bone resorption (277)

Liu X, George GC, Tsimberidou AM, Naing A, Wheler JJ, Kopetz S , Fu S, Piha-Paul SA, Eng C, Falchook GS, Janku F, Garrett CR, Karp DD, Kurzrock R, Zinner R, Raghav KPS, Subbiah V, Meric-Bernstam F, Hong DS, Overman MJ