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First, the sulfonation reaction saturates and that allows more NAPQI to accumulate ([7, 24]) and second, the increased amount of NAPQI exhausts the liver stores of reduced glutathione (GSH)[6] as well as the livers capacity to synthesize new GSH

Kerksick, C., Willoughby, D

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* This means that patients with FL who receive rituximab treatment have a weaker antibody response and produce fewer antibodies to the vaccination because they have fewer B cells to generate that type of immune response