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While NAC has been studied for renal protection (contrast-induced nephropathy), dosing adjustments may be necessary in severe renal impairment, and monitoring is advisable [67][68]

Therefore, attempting to develop a Cas14-based biosensor for versatile aptasensing that is inexpensive, fast, and direct is worth it

1 2 3 "Vitamin B12, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation" (PDF)

4 Expression of S.thermophilus GshF can modulate cellular GSH levels in mammalian cells

Because cysteine is the rate-limiting amino acid for glutathione synthesis, a decrease of cysteine will result in the low glutathione levels seen in individuals with impairment of this pathway