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Alcohol and its breakdown products affect liver genes and DNA

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The abundance of natural 13 C-labeled metabolite in ARP1 cells cultured with 13 C 2 -glycine was calculated by the following formula: abundance of natural 13 C-labeled metabolite = abundance of non 13 C-labeled metabolite P 0

BPTES) or SLC1A5 (GPNA), the key enzyme and glutamine transporter whose activities are crucial for the process ( Figure 4a ), substantially rescued the viability of Erastin-treated LDHB KD A549 cells ( Figure 4e ), indicating that LDHB KD/Erastin inhibits cell viability through glutaminolysis