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5 presents a cross-validated partial least squares discriminant analysis model integrating neuroimmune (acute phase response, serum monomeric/pentameric CRP, IRS/CIRS), metabolic (serum triglycerides, ApoA1, ApoB/ApoA1 ratio, RCT index, phospholipid remodeling, lipotoxicity, mitochondrial dysfunction, ether lipids/plasmalogens, and an insulin resistance index), and redox (oxHDL, HDL-C/oxHDL ratio, PON1, total antioxidant status) pathways

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The extraction from a sample of 100 l whole blood was done in non-buffered mixture of alcohols heated to induce protein unfolding 27 , releasing non-covalently bound cofactors while preserving redox-sensitive metabolites

These processes synchronize cell differentiation and transcriptional reprogramming, preserving K homeostasis and optimizing root system exploration