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The pharmacokinetics of esomeprazole in adult patients with symptomatic GERD following repeated once daily administration of 20 mg and 40 mg NEXIUM delayed-release capsules over a period of five days are shown in Table 6: Esomeprazole is a time-dependent inhibitor of CYP2C19, resulting in autoinhibition and nonlinear pharmacokinetics

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The subjects in each group were randomly assigned to the experimental group or the control group at a ratio of 3:1

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