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First, it is able to accumulate specifically in tumor cells, remaining unaffected by MRP while maintaining good cell-membrane permeability

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25,26,27 We also previously showed that these cells exhibit low immunogenicity and exert immunosuppressive effects through PGE2-induced T-cell anergy, 28 and regulate humoral immune responses by secreting interleukin-6, which enhances B-cell viability while inhibiting B-cell proliferation, differentiation, and migration