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Severe symptoms may require hospitalization

Youles M, Holmes O, Petoukhov MV, Nessen MA, Stivala S, Svergan DI, et al

Similar to the in vitro hMOR binding and functional studies, mitragynine also exhibited the weakest antinociceptive effect (E max 17.3%) among the tested alkaloids at the highest dose tested (10 mg/kg, i.v.)