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3.3.5 Microbiome and metabolite therapy Its tangential but notable that the gut microbiome can release metabolites (like short-chain fatty acids) that influence host mitochondria and immunity

Based on the immune regulatory function of SI mentioned above, although its immune regulation may be less associated with RA, it may play a certain role in other autoimmune diseases

Given asthmas immunological complexity and heterogeneous inflammatory endotypes, further mechanistic and long-term studies including randomized clinical trials are warranted to clarify the role of GLP-1RAs in asthma management

This concern is particularly relevant given the increasing popularity of off-label B12 use

Additionally, phagocytic and chemotactic activity of macrophages also decreased by a decline in production of macrophage-specific chemokines, including macrophage inflammatory protein (MIP)-1 and MIP-2 with advanced age