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Aside from producing anaplerotic -KG for the TCA cycle, the GDH pathway is also associated with various cellular processes, including acidbase balance, ammonia metabolism, lactate production, redox homeostasis, and lipid biosynthesis (127)

pneumoniae (127)] and PGNB [e.g., E.coli (128), H

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107 Similarly, ER stress, a hallmark of metabolic diseases, places additional demand on the UPS through the activation of the UPR

It plays a crucial role in protecting cells from oxidative stress and damage