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Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21

Each PCR product was sub-cloned into pDONR-Zeo (Invitrogen) or pGEM-T Easy vectors (Promega) for further experiments

Acknowledgments Thanks for the platform of the BioRender enables us to make high-quality figures ( We sincerely thanks to all members of our research team for their wholehearted efforts and the support from the doctoral start-up fund of the Second Affiliated Hospital of Nanchang University (B3150), and the Natural Science Foundation of Jiangxi Province (20232BAB216042), Key Research and Development projects in Jiangxi (20223BBG71010), the Science and Technology Project of Jiangxi Provincial Administration of Traditional Chinese Medicine (2023A0339)

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