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These insights underscore the need for combinatorial therapies that integrate epigenetic modulation, pathway inhibition, and apoptotic sensitization to overcome adaptive resistance (Tables 3 and 4) [160]

The important clue is that free iron is not as cytotoxic as hemin, as shown by incubations with iron (FeCl 2 and FeCl 3 ) that are not toxic in culture (preliminary data at [71]) and by knowing that the structure of hemin itself contributes to its toxicity [225]

Formation of atheroma Endothelial cells secret small peptides such as cytokines and growth factors like interleukin 1 (IL-1) and TNF causing smooth muscle cell migration and synthesized extracellular matrix

Moreover, Mn also downregulates the expression of Bcl2, an anti-apoptotic protein, in this case, consequently resulting in more apoptosis (Yang Y

The effect of the decrease in serum levels of dehydroepiandrosterone (DHEA) and hirsutism occurs by improving insulin metabolism markers