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For example, a 0.5 mg daily dose becomes 0.25 mg in the morning and 0.25 mg in the evening

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It is a base, e.g., for the deprotonation of ketones to form sodium enolates, phosphonium salts to form Wittig reagents, and formamidinium salts to form diaminocarbenes

The structures referenced in Fig

however, it could be adjusted up or down depending on how the patient is doing and their medical situation