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35 (2020) E127E135

Additionally, failure of antioxidant cascades, influenced by defects in the transcription factor Nrf2 47 , and the activation of redox-sensitive pathways regulated by the transcription factor NF-B contribute to this process 48 This activation triggers molecular cascades associated with p53/p21 (due to persistent double-strand breaks and telomere shortening) and p16/Rb (due to epigenetic modifications) 49

Importantly, arginine deprivation therapy has been shown to alleviate fibrosis in vivo and enhance the antifibrotic efficacy of nintedanib [88]

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HII built the amphibious transport soon after receiving its construction contract in 2000, laid her keel in 2003, christened in 2006, and commissioned it in 2009