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Among them, UQCRB is one of the subunits of the mitochondrial respiratory chain complex III, and mutations in UQCRB increase mtROS production and activate HIF-1 transactivation, promoting vascular neovascularization, a process that can be regulated by UQCRB inhibitors (209)

Characterisation of homologous recombination deficiency in paired primary and recurrent high-grade serous ovarian cancer

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166 The tumor suppressor p53 and the cytoskeletal protein -tubulin are two representative substrates of HDACs

10.1126/scitranslmed.aay6218 66 KhannaK.MishraK