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doi: 10.3389/fneur.2026.1772036 Received 29 December 2025 Revised 30 January 2026 Accepted 03 February 2026 Published 26 February 2026 Volume 17 - 2026 Edited by Daniele Corbo, University of Brescia, Italy Reviewed by Longfei Xu, Sciences (Academy of Military Medical AMMS), China Ali Namvaran, University of Nebraska Medical Center, United States Updates Copyright 2026 Xiao, Yan, Liang and Yang

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A depletion in NAD + results in bioenergetic failure of mitochondria and eventually cell death 90,91

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