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Halford, Jason CG

Although there is no formal recommendation for screening for vitamin B 12 deficiency in asymptomatic elderly people, the high prevalence, higher risk of deficiency in the elderly, easy and safe treatment availability warrant more liberal testing and vitamin supplementation in the elderly

After that, its efficacy may begin to decline

Cyanocobalamin, the most common, readily available and stable form of artificial vitamin B12, tends to get largely and extensively destroyed by the rumen microbes so that very little of it, if any, gets utilized in a cows body beyond the rumen

However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo