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Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Streeter et al., 1984)

Hepatocyte growth factor improves functional recovery by attenuating endoplasmic reticulum stress-induced apoptosis in peripheral nerve injury

[37]) and the cytosolic phytochelatin synthase PCS1 (At5g44070

However, clinical trial results are not so satisfactory due to difficulties in targeted delivery to diseased tissues and the potential disruption of ROS-associated physiological signaling pathways [270]