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Squalamine, a natural steroidal compound, causes changes in vascular endothelial cell shape and has been reported to possess significant antiangiogenic activity in models of lung, breast, brain and ovarian cancer

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(2015) have analysed that, compared to the untreated control group, the metastatic tumour-bearing animals treated with pepino melon extract concurrently had lung nodule inhibition of 73.6% [15]

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