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2141-A ASSOCIATION BETWEEN NON-ALCOHOLIC FATTY LIVER DISEASE AND CORONARY ARTERY DISEASE OUTCOMES: A SYSTEMATIC REVIEW AND META-ANALYSIS Hazem Abosheaishaa 1 , Islam Mohamed 2 , Muhammad Ghallab 1 , Ahmed Alzamzamy 3 , Natalie Balassiano 1 , Jawad Khan 1 , Moataz Yousry Soliman 4 , Moaz Elshair 5 , Mai Hussein 6 , Md Ripon Ahammed 1 , Muhammad Almas Baig 1 , Amr Ali 7 , Mohammed Abdelwahed 7 , Ahmed Omran 8 and Mahmoud Nassar 1 , (1)Icahn School of Medicine at Mount Sinai, (2)University of Missouri- Kansas City, (3)Department of Gastroenterology and Hepatology, Maadi Armed Forces Medical Complex, Military Medical Academy, Cairo, Egypt, (4)Faculty of Medicine, Al-Azhar University, (5)Faculty of Medicine , Al-Azhar University, (6)Clinical Research Administration/ Ministry of Health and Population, Egypt, (7)Department of Pathology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Uniondale, New York., (8)Trmc/Rwjbh , Rutgers Njms Background: To evaluate the association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular outcomes, including angina, coronary artery disease (CAD), coronary artery calcification (CAC), myocardial infarction (MI), and calcified coronary plaques

Taken together, these findings suggest a complex relationship among normal ROS flux, heightened ROS generation, and (patho)biological processes that can be regulated, in part, by GPx-1

Importantly, the study demonstrated that combining cetuximab with orlistat can inhibit the growth of CSN6-high patient-derived xenograft (PDX) tumors

Improved mitochondrial integrity and DNA repair