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General characterization of nanoparticles The size distribution of NP2 and NP4 was detected via a dynamic light scattering device (Malvern Zetasizer Nano, UK)

Sp1 regulates basal NOS3 expression and responds to stimuli like growth factors and hypoxia, enhancing NO production to maintain vascular tone (Tang et al., 1995

A biomarker is the assessment of a biological, pathological, or pharmacological process

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Furthermore, increased ACE2 expression in alveolar type II pneumocytes and alveolar macrophages of individuals with severe SARS-CoV-2 disease (ARDS with diffuse alveolar damage) requiring mechanical ventilation (Baker et al., 2021) favors a concomitant increase in oxidative stress in those individuals