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Moreover, evidence suggests that HIF-2 plays a role in maintaining CSC traits through the activation of WNT and NOTCH signaling 148 by elevating superoxide dismutase (SOD) levels and by reducing mitochondrial reactive oxygen species (ROS) levels 149

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Administration Routes Discussed in Medical Literature Administration routes discussed in the literature include oral study tablets, intravesical administration, intra-articular injection in a clinical report, and IV or IM administration in animal pharmacokinetic studies [10] [12] [13] [14]