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For instance, lactate plays a dual role in aerobic metabolism: it serves not only as an important energy substrate but also contributes to antioxidant defense

Strictly defined time-period of interest : covariate layers need to match the distribution of O&M's in the time domain, i.e., there needs to be enough training points spread across the period of interest (in this case 20002022+)

PLoS Biology , 19 (12), e3001480

Advanced Glutathione is in its reduced (active) form

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