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The intercalative conformation of these adducts in free DNA has been ascribed to the C9-OH and C8-OH hydroxyl groups pointing inward toward the DNA backbone, which lends to an already crowded situation in the minor groove of DNA 51

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Once ALA is generated, it must be exported to the cytosol via an unidentified transporter, although there are indications that ABCB10 might be involved in this process 27,28

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